Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease caused by traumatic brain injury (TBI). While the immune response to TBI is complex, the creation of abnormal tau protein into neurofibrillary tangles is a hallmark feature. Microglia, the innate immune cells of the brain, produce a low level inflammation associated with CTE Cannabidiol (CBD), the main non-psychoactive cannabinoid, has been previously shown to decrease inflammation in the brain.
CBD leads to changes in regulatory molecules on CD4 T cells which helps to promote anti inflammatory genes such as IL-10 (anti-inflammatory cytokine). While to date, there is no clinical study assessing the neuroprotective potential of CBD in CTE, there is also no known drug intervention to treat this progressive disorder. As CBD is remarkably safe, we need more clinical research to support the rationale for its use in conditions of excessive inflammation in the brain, such as CTE